Emerging Role of Epigenetics in Understanding Migraine
An individual’s susceptibility to migraine involves a complex interplay between genes (nature) and environment (nurture). Well indoctrinated into the lexicon of migraine is the concept of a migraine threshold, a physiological set point where genetics and the environment interact to create the perfect storm of molecular events that trigger migraine. Epigenetics is the study of how genes can be activated or inactivated in response to environmental influences and lifestyle choices without changing the DNA sequence. Based on recent epigenetic findings, a model for understanding migraine is proposed in this activity that may help explain risk factors, disease progression, headache phenotypes, drug response, and the critical contribution of lifestyle, medication, and stress on migraine pathology.
Faculty: Roger K. Cady, MD, and Paul L. Durham, PhD
This 1-hour CME activity is designed for all clinicians who treat chronic pain.
Upon completion of this activity, participants should be better able to:
- Discuss the role of both genes and environment on an individual’s susceptibilty to migraine.
- Explain the risk factors associated with migraine and their effects on migraine pathology.
Roger K. Cady, MD, has been Vice President of Neurology at Alder Biopharmaceuticals, Inc., in Bothell, Washington, since May 9, 2016. In addition, he founded and served as the Medical Director of the Headache Care Center, and was the founder of Clinvest and Primary Care Network. He also served as Medical Director for the Shealy Institute in Springfield, Missouri. Dr. Cady is well known for his pivotal contributions in the field of headache and migraine management. A Fellow of the American Headache Society, he also is a member of the Board of Directors for the National Headache Foundation (NHF).
Paul L. Durham, PhD, is Distinguished Professor of Cell Biology at Missouri State University in Springfield and Director of its Center for Biomedical and Life Sciences, a multidisciplinary laboratory that utilizes cellular/molecular, microbiological, biochemical, and chemical techniques.
Staff and Content Validation Reviewer Disclosures
The staff involved with this activity and any content validation reviewers of this activity have reported no relevant financial relationships with commercial interests.
Planning Committee/Faculty Disclosure
Dr. Cady reports that he is VP Neurology at Alder Biopharmaceuticas.
Dr. Durham reports that he receives grant support from IDF, Banyon Group, electoCore, Tuning Elements, and CBD Life Sciences.
Debra Nelson-Hogan, Director of Education for the Academy of Integrative Pain Management, reports that she has nothing to disclose.
Cathleen Coneghen, Assistant Director of Education for the Academy of Integrative Pain Management, reports that she has nothing to disclose.
The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a health care provider relative to diagnostic and treatment options of a specific patient’s medical condition.
For questions regarding CME for this activity, you may reach the department of education at the Academy of Integrative Pain Management at firstname.lastname@example.org.
For successful completion of this activity, please complete a pre-test; review the article information, and complete a post-test and evaluation following the activity. You will then be prompted to print your certificate. This activity should take approximately 1 hour to complete.
This program is accredited for physicians, nurses, and psychologists. All other clinicians can submit the certificate of attendance upon completion of the program to their licensing boards for consideration of credit.
The Academy of Integrative Pain Management is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The Academy of Integrative Pain Management designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
The Academy of Integrative Pain Management is approved by the California Board of Registered Nursing, Provider Number CEP 15881 for 1 contact hour.
The Academy of Integrative Pain Management is approved by the American Psychological Association to sponsor continuing education for psychologists. The American Academy of Pain Management maintains responsibility for this program and its content.
The Academy designates this activity for a maximum of 1 CE credit.
- 1.00 AMA PRA Category 1 Credit(s)™
- 1.00 APA
- 1.00 Document of Attendance
- 1.00 Nursing Credit